Burkholderia thailandensis E264 ATCC 700388, BTH_II0840 (bicA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II0840
NCBI Locus TagBTH_RS04365
Name
bicA
Replicon chromosome II
Genomic location 980710 - 981225 (+ strand)
Transposon Mutants 1 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq YP_439037.1
GI 83716418
Entrez 3845002
GI 83716418
INSDC AIP29460.1
NCBI Locus Tag BTH_RS04365
NCBI Old Locus Tag BTH_II0840
RefSeq WP_009896148.1
UniParc UPI00006673D2
UniProtKB Acc Q2T712
UniProtKB ID Q2T712_BURTA
UniRef100 UniRef100_Q2T712
UniRef50 UniRef50_Q7NUS7
UniRef90 UniRef90_I1WUC1

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion chaperone BicA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -8.20
Kyte-Doolittle Hydrophobicity Value -0.185
Molecular Weight (kDa) 19273.5
Isoelectric Point (pI) 4.62

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000250
sequence similarity evidence used in manual assertion
Host Organism
Notes
Annotation transferred from Burkholderia pseudomallei K96243
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 28 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019836 (323 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II0840
Search term: bicA

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Type III secretion chaperone-dependent regulation: activation of virulence genes by SicA and InvF in Salmonella typhimurium.
Darwin KH, Miller VL
EMBO J 2001 Apr 17;20(8):1850-62
PubMed ID: 11296219