Burkholderia thailandensis E264 ATCC 700388, BTH_II0690 (bceN)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II0690
NCBI Locus TagBTH_RS03595
Name
bceN
Synonym: gmd-2
Replicon chromosome II
Genomic location 806188 - 807231 (- strand)
Transposon Mutants 4 transposon mutants in E264 ATCC 700388
CommentMember of the bce-II gene cluster

Cross-References

RefSeq YP_438889.1
GI 83716887
Entrez 3845178
GI 83716887
INSDC AIP27483.1
NCBI Locus Tag BTH_RS03595
NCBI Old Locus Tag BTH_II0690
RefSeq WP_009895868.1
UniParc UPI000066759A
UniProtKB Acc Q2T7G0
UniProtKB ID Q2T7G0_BURTA
UniRef100 UniRef100_Q2T7G0
UniRef50 UniRef50_Q2T7G0
UniRef90 UniRef90_Q2T7G0

Product

Feature Type CDS
Coding Frame 1
Product Name
GDP-D-mannose 4,6-dehydratase BceN
Product Name Confidence: Class 2
Synonyms GDP-mannose 4,6-dehydratase
Evidence for Translation
Charge (pH 7) 2.39
Kyte-Doolittle Hydrophobicity Value -0.283
Molecular Weight (kDa) 38906.0
Isoelectric Point (pI) 8.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 608 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003102 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II0690
Search term: bceN

Human Homologs

Ensembl 97, assembly GRCh38.p12
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
E-value: 1.0e-97
Percent Identity: 52.9

References

Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase.
Sousa SA, Feliciano JR, Pinheiro PF, Leitão JH
PLoS One 2013;8(2):e56902
PubMed ID: 23460819
Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863