Burkholderia thailandensis E264 ATCC 700388, BTH_II0690 (bceN)

Gene Feature Overview

Strain	Burkholderia thailandensis E264 ATCC 700388 GCF_000012365.1|latest
Locus Tag	BTH_II0690
NCBI Locus Tag	BTH_RS03595
Name	bceN Synonym: gmd-2
Replicon	chromosome II
Genomic location	806188 - 807231 (- strand)
Transposon Mutants	4 transposon mutants in E264 ATCC 700388
Comment	Member of the bce-II gene cluster

Cross-References

RefSeq	YP_438889.1
GI	83716887
Entrez	3845178
GI	83716887
INSDC	AIP27483.1
NCBI Locus Tag	BTH_RS03595
NCBI Old Locus Tag	BTH_II0690
RefSeq	WP_009895868.1
UniParc	UPI000066759A
UniProtKB Acc	Q2T7G0
UniProtKB ID	Q2T7G0_BURTA
UniRef100	UniRef100_Q2T7G0
UniRef50	UniRef50_Q2T7G0
UniRef90	UniRef90_Q2T7G0

Product

Feature Type	CDS
Coding Frame	1
Product Name	GDP-D-mannose 4,6-dehydratase BceN Product Name Confidence: Class 2
Synonyms	GDP-mannose 4,6-dehydratase
Evidence for Translation
Charge (pH 7)	2.39
Kyte-Doolittle Hydrophobicity Value	-0.283
Molecular Weight (kDa)	38906.0
Isoelectric Point (pI)	8.18

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 608 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG003102 (653 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BTH_II0690 Search term: bceN Search term: GDP-D-mannose 4,6-dehydratase BceN

Human Homologs

Ensembl 97, assembly GRCh38.p12

ENSP00000370194 GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369] E-value: 1.0e-97 Percent Identity: 52.9

References

Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase. Sousa SA, Feliciano JR, Pinheiro PF, Leitão JH PLoS One 2013;8(2):e56902 PubMed ID: 23460819

Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions. Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM Appl Environ Microbiol 2010 Jan;76(2):441-50 PubMed ID: 19948863