Burkholderia thailandensis E264 ATCC 700388, BTH_II0554 (fbp)

Gene Feature Overview

Strain	Burkholderia thailandensis E264 ATCC 700388 GCF_000012365.1|latest
Locus Tag	BTH_II0554
NCBI Locus Tag	BTH_RS02890
Name	fbp
Replicon	chromosome II
Genomic location	658713 - 659054 (- strand)
Transposon Mutants	1 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq	YP_438754.1
GI	83716167
Entrez	3845881
GI	83716167
INSDC	AIP28683.1
NCBI Locus Tag	BTH_RS02890
NCBI Old Locus Tag	BTH_II0554
RefSeq	WP_009895623.1
UniParc	UPI00006672DF
UniProtKB Acc	Q2T7U5
UniProtKB ID	Q2T7U5_BURTA
UniRef100	UniRef100_Q2T7U5
UniRef50	UniRef50_Q2T7U5
UniRef90	UniRef90_Q2T7U5

Product

Feature Type	CDS
Coding Frame	1
Product Name	FK506-binding protein
Synonyms
Evidence for Translation
Charge (pH 7)	-3.77
Kyte-Doolittle Hydrophobicity Value	-0.110
Molecular Weight (kDa)	11914.4
Isoelectric Point (pI)	4.59

Subcellular localization

Individual Mappings	Localization Confidence PMID Periplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
3UQB	Isomerase, protein binding	11/19/11	Crystal structure of a SMT Fusion PEPTIDYL-PROLYL CIS-TRANS ISOMERASE with surface mutation D44G from Burkholderia pseudomallei complexed with FK506	SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI	1.9	X-RAY DIFFRACTION	98.2
4DZ3	ISOMERASE	02/29/12	Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation M61H from Burkholderia pseudomallei complexed with FK506	BURKHOLDERIA PSEUDOMALLEI	2.0	X-RAY DIFFRACTION	98.2
4G50	Isomerase, protein binding	07/17/12	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168	SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI	1.75	X-RAY DIFFRACTION	98.2
5V8T	ISOMERASE	03/22/17	Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354	SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); BURKHOLDERIA PSEUDOMALLEI	2.1	X-RAY DIFFRACTION	99.1
4GGQ	Isomerase, protein binding	08/07/12	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40	SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI	1.95	X-RAY DIFFRACTION	99.1
4DZ2	ISOMERASE	02/29/12	Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation R92G from Burkholderia pseudomallei complexed with FK506	BURKHOLDERIA PSEUDOMALLEI	2.0	X-RAY DIFFRACTION	98.2
5KLX	ISOMERASE, protein binding	06/26/16	Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110	SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B)	2.45	X-RAY DIFFRACTION	99.1
2L2S	ISOMERASE	08/27/10	Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with 1-{[(4-methylphenyl)thio]acetyl}piperidine	BURKHOLDERIA PSEUDOMALLEI	NOT	SOLUTION NMR	98.2
2KO7	ISOMERASE	09/11/09	Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with Cycloheximide-N-ethylethanoate	BURKHOLDERIA PSEUDOMALLEI	NOT	SOLUTION NMR	98.2
3UQA	Isomerase, protein binding	11/19/11	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation A54E from Burkholderia pseudomallei complexed with FK506	SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI	1.55	X-RAY DIFFRACTION	98.2
3VAW	Isomerase, PROTEIN BINDING/INHIBITOR	12/29/11	Crystal structure of a smt fusion peptidyl-prolyl cis-trans isomerase with surface mutation v3i from burkholderia pseudomallei complexed with fk506	SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); BURKHOLDERIA PSEUDOMALLEI	1.55	X-RAY DIFFRACTION	98.2
3UF8	Isomerase, protein binding	10/31/11	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506	SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI	1.5	X-RAY DIFFRACTION	98.2
2Y78	ISOMERASE	01/28/11	Crystal structure of BPSS1823, a Mip-like chaperone from Burkholderia pseudomallei	BURKHOLDERIA PSEUDOMALLEI	0.91	X-RAY DIFFRACTION	98.2
2KE0	ISOMERASE	01/21/09	Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei	BURKHOLDERIA PSEUDOMALLEI	NOT	SOLUTION NMR	98.2
4FN2	Isomerase, protein binding	06/19/12	Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37	SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI	1.95	X-RAY DIFFRACTION	98.2

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 430 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG004859 (637 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BTH_II0554 Search term: fbp Search term: FK506-binding protein

Human Homologs

Ensembl 97, assembly GRCh38.p12	ENSP00000383003 FKBP prolyl isomerase 1A [Source:HGNC Symbol;Acc:HGNC:3711] E-value: 2.0e-26 Percent Identity: 56.7
Ensembl 97, assembly GRCh38.p12	ENSP00000371138 FKBP prolyl isomerase 1A [Source:HGNC Symbol;Acc:HGNC:3711] E-value: 2.0e-26 Percent Identity: 56.7

References