Burkholderia thailandensis E264 ATCC 700388, BTH_II0554 (fbp)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II0554
NCBI Locus TagBTH_RS02890
Name
fbp
Replicon chromosome II
Genomic location 658713 - 659054 (- strand)
Transposon Mutants 1 transposon mutants in E264 ATCC 700388

Cross-References

RefSeq YP_438754.1
GI 83716167
Entrez 3845881
GI 83716167
INSDC AIP28683.1
NCBI Locus Tag BTH_RS02890
NCBI Old Locus Tag BTH_II0554
RefSeq WP_009895623.1
UniParc UPI00006672DF
UniProtKB Acc Q2T7U5
UniProtKB ID Q2T7U5_BURTA
UniRef100 UniRef100_Q2T7U5
UniRef50 UniRef50_Q2T7U5
UniRef90 UniRef90_Q2T7U5

Product

Feature Type CDS
Coding Frame 1
Product Name
FK506-binding protein
Synonyms
Evidence for Translation
Charge (pH 7) -3.77
Kyte-Doolittle Hydrophobicity Value -0.110
Molecular Weight (kDa) 11914.4
Isoelectric Point (pI) 4.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2KE0 ISOMERASE 01/21/09 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 98.2
4GGQ Isomerase, protein binding 08/07/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.95 X-RAY DIFFRACTION 99.1
5V8T ISOMERASE 03/22/17 Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 99.1
2L2S ISOMERASE 08/27/10 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with 1-{[(4-methylphenyl)thio]acetyl}piperidine BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 98.2
4DZ2 ISOMERASE 02/29/12 Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation R92G from Burkholderia pseudomallei complexed with FK506 BURKHOLDERIA PSEUDOMALLEI 2.0 X-RAY DIFFRACTION 98.2
3VAW Isomerase, PROTEIN BINDING/INHIBITOR 12/29/11 Crystal structure of a smt fusion peptidyl-prolyl cis-trans isomerase with surface mutation v3i from burkholderia pseudomallei complexed with fk506 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); BURKHOLDERIA PSEUDOMALLEI 1.55 X-RAY DIFFRACTION 98.2
4DZ3 ISOMERASE 02/29/12 Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation M61H from Burkholderia pseudomallei complexed with FK506 BURKHOLDERIA PSEUDOMALLEI 2.0 X-RAY DIFFRACTION 98.2
3UF8 Isomerase, protein binding 10/31/11 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.5 X-RAY DIFFRACTION 98.2
3UQB Isomerase, protein binding 11/19/11 Crystal structure of a SMT Fusion PEPTIDYL-PROLYL CIS-TRANS ISOMERASE with surface mutation D44G from Burkholderia pseudomallei complexed with FK506 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.9 X-RAY DIFFRACTION 98.2
3UQA Isomerase, protein binding 11/19/11 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation A54E from Burkholderia pseudomallei complexed with FK506 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.55 X-RAY DIFFRACTION 98.2
5KLX ISOMERASE, protein binding 06/26/16 Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 2.45 X-RAY DIFFRACTION 99.1
2KO7 ISOMERASE 09/11/09 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with Cycloheximide-N-ethylethanoate BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 98.2
4G50 Isomerase, protein binding 07/17/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.75 X-RAY DIFFRACTION 98.2
4FN2 Isomerase, protein binding 06/19/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.95 X-RAY DIFFRACTION 98.2
2Y78 ISOMERASE 01/28/11 Crystal structure of BPSS1823, a Mip-like chaperone from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 0.91 X-RAY DIFFRACTION 98.2

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 430 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004859 (637 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II0554
Search term: fbp

Human Homologs

Ensembl 97, assembly GRCh38.p12
FKBP prolyl isomerase 1A [Source:HGNC Symbol;Acc:HGNC:3711]
E-value: 2.0e-26
Percent Identity: 56.7
Ensembl 97, assembly GRCh38.p12
FKBP prolyl isomerase 1A [Source:HGNC Symbol;Acc:HGNC:3711]
E-value: 2.0e-26
Percent Identity: 56.7

References

No references are associated with this feature.