Burkholderia thailandensis E264 ATCC 700388, BTH_II0544 (bceC)

Cytoplasmic Membrane
Outer Membrane
View in JBrowse

Gene Feature Overview

Strain Burkholderia thailandensis E264 ATCC 700388
Locus Tag
NCBI Locus TagBTH_RS02840
Replicon chromosome II
Genomic location 646516 - 647937 (+ strand)
Transposon Mutants 1 transposon mutants in E264 ATCC 700388
CommentMember of the bce-I gene cluster


RefSeq YP_438744.1
GI 83717367
Entrez 3846660
GI 83717367
NCBI Locus Tag BTH_RS02840
NCBI Old Locus Tag BTH_II0544
RefSeq WP_009907281.1
UniProtKB Acc Q2T7V5


Feature Type CDS
Coding Frame 1
Product Name
UDP-Glucose Dehydrogenase BceC
Product Name Confidence: Class 2
Synonyms UDP-glucose 6-dehydrogenase
Evidence for Translation
Charge (pH 7) -1.96
Kyte-Doolittle Hydrophobicity Value -0.158
Molecular Weight (kDa) 51253.7
Isoelectric Point (pI) 6.61

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000893 (1284 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II0544
Search term: bceC

Human Homologs

Ensembl 97, assembly GRCh38.p12
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 4.5e-67
Percent Identity: 36.0
Ensembl 97, assembly GRCh38.p12
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 4.5e-67
Percent Identity: 36.0


Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate.
Rocha J, Popescu AO, Borges P, Mil-Homens D, Moreira LM, Sá-Correia I, Fialho AM, Frazão C
J Bacteriol 2011 Aug;193(15):3978-87
PubMed ID: 21602353
Cloning, expression, purification, crystallization and preliminary crystallographic studies of BceC, a UDP-glucose dehydrogenase from Burkholderia cepacia IST408.
Rocha J, Popescu AO, Sá-Correia I, Fialho AM, Frazão C
Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Mar 1;66(Pt 3):269-71
PubMed ID: 20208157