Burkholderia thailandensis E264; ATCC 700388, BTH_II0255 (tagF-6)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia thailandensis E264; ATCC 700388
GCF_000012365.1|latest
Locus Tag
BTH_II0255
NCBI Locus TagBTH_RS01325
Name
tagF-6
Replicon chromosome II
Genomic location 312486 - 313352 (+ strand)
Transposon Mutants 1 transposon mutants in E264; ATCC 700388
CommentThis gene is part of cluster known as the type VI secretion system gene cluster tss-6 based on naming convention used for B. pseudomallei described in PMID:17660433, however unlike B. pseudomallei, the numbers following the vgrG and hcp gene match the cluster number (PMID:20865170).

Cross-References

RefSeq YP_438457.1
GI 83716732
Entrez 3845335
GI 83716732
INSDC ABC34621.1
NCBI Locus Tag BTH_RS01325
NCBI Old Locus Tag BTH_II0255
RefSeq YP_438457.1
UniParc UPI0000667500
UniProtKB Acc Q2T8P2
UniProtKB ID Q2T8P2_BURTA
UniRef100 UniRef100_A0A096YV88
UniRef50 UniRef50_I1WW30
UniRef90 UniRef90_A0A096ZD83

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system-associated protein TagF-6
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -0.71
Kyte-Doolittle Hydrophobicity Value -0.374
Molecular Weight (kDa) 30623.9
Isoelectric Point (pI) 6.78

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 46 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG016591 (491 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BTH_II0255
Search term: tagF-6

References

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.
Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD.
PLoS Pathog. 2010 Aug 26;6(8)
PubMed ID: 20865170
In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434