Burkholderia pseudomallei K96243, BPSS2200 (tyrB2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS2200
Name
tyrB2
Replicon chromosome 2
Genomic location 2967370 - 2968587 (+ strand)

Cross-References

RefSeq YP_112202.1
GI 53723217
Entrez 3096804
GI 53723217
INSDC CAH39685.1
NCBI Locus Tag BPSS2200
RefSeq YP_112202.1,GeneID
UniParc UPI000043BFB1
UniProtKB Acc Q63I70
UniProtKB ID Q63I70_BURPS
UniRef100 UniRef100_Q3JIX5
UniRef50 UniRef50_S0AF83
UniRef90 UniRef90_A3P9J0

Product

Feature Type CDS
Coding Frame 1
Product Name
aromatic amino acid aminotransferase
Synonyms
Evidence for Translation
Charge (pH 7) 3.46
Kyte-Doolittle Hydrophobicity Value -0.058
Molecular Weight (kDa) 44221.8
Isoelectric Point (pI) 7.89

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 185 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG021099 (393 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS2200
Search term: tyrB2

Human Homologs

Ensembl 97, assembly GRCh38.p12
glutamic-oxaloacetic transaminase 2 [Source:HGNC Symbol;Acc:HGNC:4433]
E-value: 6.5e-91
Percent Identity: 41.8

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268