Burkholderia pseudomallei K96243, BPSS1833 (bceC)

Cytoplasmic Membrane
Outer Membrane
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
Locus Tag
Synonym: udg2
Replicon chromosome 2
Genomic location 2492704 - 2494125 (- strand)
CommentMember of the bce-I gene cluster


RefSeq YP_111837.1
GI 53722852
Entrez 3096805
GI 53722852
INSDC CAH39309.1
NCBI Locus Tag BPSS1833
RefSeq YP_111837.1,GeneID
UniParc UPI000043BE46
UniProtKB Acc Q63J85
UniRef100 UniRef100_Q63J85
UniRef50 UniRef50_O86422
UniRef90 UniRef90_Q63J85


Feature Type CDS
Coding Frame 1
Product Name
UDP-Glucose Dehydrogenase BceC
Product Name Confidence: Class 2
Synonyms UDP-glucose 6-dehydrogenase 2
Evidence for Translation
Charge (pH 7) -7.96
Kyte-Doolittle Hydrophobicity Value -0.124
Molecular Weight (kDa) 51045.3
Isoelectric Point (pI) 5.53

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 588 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000893 (1284 members)
Putative Inparalogs None Found


STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1833
Search term: bceC

Human Homologs

Ensembl 97, assembly GRCh38.p12
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 5.3e-68
Percent Identity: 36.0
Ensembl 97, assembly GRCh38.p12
UDP-glucose 6-dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12525]
E-value: 5.3e-68
Percent Identity: 36.0


Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863
Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate.
Rocha J, Popescu AO, Borges P, Mil-Homens D, Moreira LM, Sá-Correia I, Fialho AM, Frazão C
J Bacteriol 2011 Aug;193(15):3978-87
PubMed ID: 21602353
Cloning, expression, purification, crystallization and preliminary crystallographic studies of BceC, a UDP-glucose dehydrogenase from Burkholderia cepacia IST408.
Rocha J, Popescu AO, Sá-Correia I, Fialho AM, Frazão C
Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Mar 1;66(Pt 3):269-71
PubMed ID: 20208157