Burkholderia pseudomallei K96243, BPSS1823 (fbp)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1823
Name
fbp
Replicon chromosome 2
Genomic location 2481354 - 2481695 (+ strand)

Cross-References

RefSeq YP_111827.1
GI 53722842
Entrez 3094935
GI 53722842
INSDC CAH39299.1
NCBI Locus Tag BPSS1823
RefSeq YP_111827.1,GeneID
UniParc UPI000043BE3C
UniProtKB Acc Q63J95
UniProtKB ID Q63J95_BURPS
UniRef100 UniRef100_A0A069BB90
UniRef50 UniRef50_Q2T7U5
UniRef90 UniRef90_Q2T7U5

Product

Feature Type CDS
Coding Frame 1
Product Name
peptidyl-prolyl cis-trans isomerase
Synonyms
Evidence for Translation
Charge (pH 7) -3.77
Kyte-Doolittle Hydrophobicity Value -0.133
Molecular Weight (kDa) 11930.4
Isoelectric Point (pI) 4.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4GGQ Isomerase, protein binding 08/07/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.95 X-RAY DIFFRACTION 100.0
3VAW Isomerase, PROTEIN BINDING/INHIBITOR 12/29/11 Crystal structure of a smt fusion peptidyl-prolyl cis-trans isomerase with surface mutation v3i from burkholderia pseudomallei complexed with fk506 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); BURKHOLDERIA PSEUDOMALLEI 1.55 X-RAY DIFFRACTION 99.1
3UF8 Isomerase, protein binding 10/31/11 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.5 X-RAY DIFFRACTION 99.1
5V8T ISOMERASE 03/22/17 Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354 SACCHAROMYCES CEREVISIAE (STRAIN ATCC 204508 / S288C); BURKHOLDERIA PSEUDOMALLEI 2.1 X-RAY DIFFRACTION 100.0
4FN2 Isomerase, protein binding 06/19/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.95 X-RAY DIFFRACTION 99.1
4G50 Isomerase, protein binding 07/17/12 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.75 X-RAY DIFFRACTION 99.1
2KO7 ISOMERASE 09/11/09 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with Cycloheximide-N-ethylethanoate BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 100.0
2L2S ISOMERASE 08/27/10 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with 1-{[(4-methylphenyl)thio]acetyl}piperidine BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 100.0
5KLX ISOMERASE, protein binding 06/26/16 Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 2.45 X-RAY DIFFRACTION 100.0
3UQA Isomerase, protein binding 11/19/11 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation A54E from Burkholderia pseudomallei complexed with FK506 SACCHAROMYCES CEREVISIAE; BURKHOLDERIA PSEUDOMALLEI 1.55 X-RAY DIFFRACTION 99.1
4DZ2 ISOMERASE 02/29/12 Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation R92G from Burkholderia pseudomallei complexed with FK506 BURKHOLDERIA PSEUDOMALLEI 2.0 X-RAY DIFFRACTION 99.1
2Y78 ISOMERASE 01/28/11 Crystal structure of BPSS1823, a Mip-like chaperone from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI 0.91 X-RAY DIFFRACTION 100.0
4DZ3 ISOMERASE 02/29/12 Crystal structure of a Peptidyl-prolyl cis-trans isomerase with surface mutation M61H from Burkholderia pseudomallei complexed with FK506 BURKHOLDERIA PSEUDOMALLEI 2.0 X-RAY DIFFRACTION 99.1
2KE0 ISOMERASE 01/21/09 Solution structure of peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei BURKHOLDERIA PSEUDOMALLEI NOT SOLUTION NMR 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 430 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004859 (637 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1823
Search term: fbp

Human Homologs

Ensembl 97, assembly GRCh38.p12
FKBP prolyl isomerase 1A [Source:HGNC Symbol;Acc:HGNC:3711]
E-value: 1.6e-26
Percent Identity: 56.7
Ensembl 97, assembly GRCh38.p12
FKBP prolyl isomerase 1A [Source:HGNC Symbol;Acc:HGNC:3711]
E-value: 1.6e-26
Percent Identity: 56.7

References

No references are associated with this feature.