Burkholderia pseudomallei K96243, BPSS1688 (bceN)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1688
Name
bceN
Synonym: gca
Replicon chromosome 2
Genomic location 2322038 - 2323081 (+ strand)
CommentMember of the bce-II gene cluster

Cross-References

RefSeq YP_111693.1
GI 53722708
Entrez 3095272
GI 53722708
INSDC CAH39161.1
NCBI Locus Tag BPSS1688
RefSeq YP_111693.1,GeneID
UniParc UPI000043BDB6
UniProtKB Acc Q63JM9
UniProtKB ID Q63JM9_BURPS
UniRef100 UniRef100_Q63JM9
UniRef50 UniRef50_Q2T7G0
UniRef90 UniRef90_Q2T7G0

Product

Feature Type CDS
Coding Frame 1
Product Name
GDP-D-mannose 4,6-dehydratase BceN
Product Name Confidence: Class 2
Synonyms GCP-mannose 4,6-dehydratase
Evidence for Translation
Charge (pH 7) 4.86
Kyte-Doolittle Hydrophobicity Value -0.259
Molecular Weight (kDa) 38860.0
Isoelectric Point (pI) 8.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 585 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003102 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1688
Search term: bceN

Human Homologs

Ensembl 97, assembly GRCh38.p12
GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369]
E-value: 5.7e-96
Percent Identity: 52.1

References

Biochemical and functional studies on the Burkholderia cepacia complex bceN gene, encoding a GDP-D-mannose 4,6-dehydratase.
Sousa SA, Feliciano JR, Pinheiro PF, Leitão JH
PLoS One 2013;8(2):e56902
PubMed ID: 23460819
Distribution of cepacian biosynthesis genes among environmental and clinical Burkholderia strains and role of cepacian exopolysaccharide in resistance to stress conditions.
Ferreira AS, Leitão JH, Silva IN, Pinheiro PF, Sousa SA, Ramos CG, Moreira LM
Appl Environ Microbiol 2010 Jan;76(2):441-50
PubMed ID: 19948863