Burkholderia pseudomallei K96243, BPSS1626 (bpscL2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1626
Name
bpscL2
Synonym: sctL
Replicon chromosome 2
Genomic location 2200225 - 2200941 (+ strand)
CommentThis gene is part of the type III secretion system T3SS-2 locus found in B. pseudomallei. B. pseudomallei T3SS-1 and T3SS-2, but not T3SS-3 contribute to pathogenicity in Solanum lycopersicum (tomato) but not human monocytic cell line THP-1. (PMID:20109238).

Cross-References

RefSeq YP_111634.1
GI 53722649
Entrez 3095590
GI 53722649
INSDC CAH39101.1
NCBI Locus Tag BPSS1626
RefSeq YP_111634.1,GeneID
UniParc UPI000043BD7D
UniProtKB Acc Q63JT8
UniProtKB ID Q63JT8_BURPS
UniRef100 UniRef100_A3P7C7
UniRef50 UniRef50_Q2T7A7
UniRef90 UniRef90_Q2T7A7

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system stator protein BpscL2 (T3SS-2)
Product Name Confidence: Class 2
Synonyms type III secretion system protein HrpB
Evidence for Translation
Charge (pH 7) -4.12
Kyte-Doolittle Hydrophobicity Value -0.269
Molecular Weight (kDa) 26047.8
Isoelectric Point (pI) 5.44

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 34 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019921 (419 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1626
Search term: bpscL2

References

Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.
Warawa J, Woods DE
FEMS Microbiol Lett 2005 Jan 1;242(1):101-8
PubMed ID: 15621426
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152