Burkholderia pseudomallei K96243, BPSS1621 (bpscU2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1621
Name
bpscU2
Synonym: sctU
Replicon chromosome 2
Genomic location 2196386 - 2197468 (- strand)
CommentThis gene is part of the type III secretion system T3SS-2 locus found in B. pseudomallei. B. pseudomallei T3SS-1 and T3SS-2, but not T3SS-3 contribute to pathogenicity in Solanum lycopersicum (tomato) but not human monocytic cell line THP-1. (PMID:20109238).

Cross-References

RefSeq YP_111629.1
GI 53722644
Entrez 3096071
GI 53722644
INSDC CAH39096.1
NCBI Locus Tag BPSS1621
RefSeq YP_111629.1,GeneID
UniParc UPI000043BD78
UniProtKB Acc Q63JU3
UniProtKB ID Q63JU3_BURPS
UniRef100 UniRef100_Q63JU3
UniRef50 UniRef50_Q3JKR4
UniRef90 UniRef90_Q3JKR4

Product

Feature Type CDS
Coding Frame 1
Product Name
autoprotease, early/middle substrate switch BpscU2 (T3SS-2)
Product Name Confidence: Class 2
Synonyms type III secretion system protein HrcU
Evidence for Translation
Charge (pH 7) 12.63
Kyte-Doolittle Hydrophobicity Value 0.192
Molecular Weight (kDa) 38914.3
Isoelectric Point (pI) 10.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
T3SS
Note: This is based on PSORTb V3.0 secondary localization prediction
Class 3
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 324 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017459 (457 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1621
Search term: bpscU2

References

Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.
Warawa J, Woods DE
FEMS Microbiol Lett 2005 Jan 1;242(1):101-8
PubMed ID: 15621426
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152