Burkholderia pseudomallei K96243, BPSS1616 (bpscS2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1616
Name
bpscS2
Synonym: sctS
Replicon chromosome 2
Genomic location 2191452 - 2191715 (- strand)
CommentThis gene is part of the type III secretion system T3SS-2 locus found in B. pseudomallei. B. pseudomallei T3SS-1 and T3SS-2, but not T3SS-3 contribute to pathogenicity in Solanum lycopersicum (tomato) but not human monocytic cell line THP-1. (PMID:20109238).

Cross-References

RefSeq YP_111624.1
GI 53722639
Entrez 3095167
GI 53722639
INSDC CAH39091.1
NCBI Locus Tag BPSS1616
RefSeq YP_111624.1,GeneID
UniParc UPI000043BD73
UniProtKB Acc Q63JU8
UniProtKB ID Q63JU8_BURPS
UniRef100 UniRef100_A0A095NBA9
UniRef50 UniRef50_Q2T797
UniRef90 UniRef90_Q2T797

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system inner membrane export apparatus protein BpscS2 (T3SS-2)
Product Name Confidence: Class 2
Synonyms type III secretion protein
Evidence for Translation
Charge (pH 7) -2.81
Kyte-Doolittle Hydrophobicity Value 1.038
Molecular Weight (kDa) 9118.7
Isoelectric Point (pI) 4.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 184 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003803 (580 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1616
Search term: bpscS2

References

Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.
Warawa J, Woods DE
FEMS Microbiol Lett 2005 Jan 1;242(1):101-8
PubMed ID: 15621426
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152