Burkholderia pseudomallei K96243, BPSS1611 (bpsaB2)

Gene Feature Overview

Strain	Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1 GCF_000011545.1|latest
Locus Tag	BPSS1611
Name	bpsaB2
Replicon	chromosome 2
Genomic location	2188230 - 2188685 (- strand)
Comment	This gene is part of the type III secretion system T3SS-2 locus found in B. pseudomallei. B. pseudomallei T3SS-1 and T3SS-2, but not T3SS-3 contribute to pathogenicity in Solanum lycopersicum (tomato) but not human monocytic cell line THP-1. (PMID:20109238).

Cross-References

RefSeq	YP_111619.1
GI	53722634
Entrez	3095885
GI	53722634
INSDC	CAH39086.1
NCBI Locus Tag	BPSS1611
RefSeq	YP_111619.1,GeneID
UniParc	UPI000043BD6E
UniProtKB Acc	Q63JV3
UniProtKB ID	Q63JV3_BURPS
UniRef100	UniRef100_A0A069BA66
UniRef50	UniRef50_Q3BYL6
UniRef90	UniRef90_A0A088X7Z6

Product

Feature Type	CDS
Coding Frame	1
Product Name	type III secretion system chaperone protein BpsaB2 (T3SS-2) Product Name Confidence: Class 2
Synonyms	hypothetical protein
Evidence for Translation
Charge (pH 7)	-16.32
Kyte-Doolittle Hydrophobicity Value	0.042
Molecular Weight (kDa)	17253.2
Isoelectric Point (pI)	3.94

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 7 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG017469 (470 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BPSS1611 Search term: bpsaB2 Search term: type III secretion system chaperone protein BpsaB2 (T3SS-2)

Human Homologs

References

Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model. Warawa J, Woods DE FEMS Microbiol Lett 2005 Jan 1;242(1):101-8 PubMed ID: 15621426

Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>. Vander Broek CW, Stevens JM Front Cell Infect Microbiol 2017;7:255 PubMed ID: 28664152