Burkholderia pseudomallei K96243, BPSS1592 (bpscC2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1592
Name
bpscC2
Synonym: sctC
Replicon chromosome 2
Genomic location 2165625 - 2167430 (- strand)

Cross-References

RefSeq YP_111600.1
GI 53722615
Entrez 3095726
GI 53722615
INSDC CAH39067.1
NCBI Locus Tag BPSS1592
RefSeq YP_111600.1,GeneID
UniParc UPI000043BD5B
UniProtKB Acc Q63JX2
UniProtKB ID Q63JX2_BURPS
UniRef100 UniRef100_A0A069BGP3
UniRef50 UniRef50_C5ALL6
UniRef90 UniRef90_Q2T775

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system outer membrane ring protein / secretin BpscC2 (T3SS-2)
Product Name Confidence: Class 2
Synonyms type III secretion system protein
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724).
Charge (pH 7) -2.33
Kyte-Doolittle Hydrophobicity Value -0.077
Molecular Weight (kDa) 63363.4
Isoelectric Point (pI) 6.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 307 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003802 (591 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1592
Search term: bpscC2

References

Type III secretion system cluster 3 is required for maximal virulence of Burkholderia pseudomallei in a hamster infection model.
Warawa J, Woods DE
FEMS Microbiol Lett 2005 Jan 1;242(1):101-8
PubMed ID: 15621426
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152