Burkholderia pseudomallei K96243, BPSS1554 (bprQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1554
Name
bprQ
Replicon chromosome 2
Genomic location 2107895 - 2108335 (+ strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111560.1
GI 53722575
Entrez 3095650
GI 53722575
INSDC CAH39027.1
NCBI Locus Tag BPSS1554
RefSeq YP_111560.1,GeneID
UniParc UPI000043BD34
UniProtKB Acc Q63K12
UniProtKB ID Q63K12_BURPS
UniRef100 UniRef100_D7SFB7
UniRef50 UniRef50_D7SFB7
UniRef90 UniRef90_D7SFB7

Product

Feature Type CDS
Coding Frame 1
Product Name
regulator of type III secretion system-3 (T3SS-3) BprQ
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 1.07
Kyte-Doolittle Hydrophobicity Value -0.086
Molecular Weight (kDa) 16129.2
Isoelectric Point (pI) 7.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Pathogenic
Found only in pathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019869 (314 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1554
Search term: bprQ

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Identification of a regulatory cascade controlling Type III Secretion System 3 gene expression in Burkholderia pseudomallei.
Sun GW, Chen Y, Liu Y, Tan GY, Ong C, Tan P, Gan YH
Mol Microbiol 2010 May;76(3):677-89
PubMed ID: 20345664
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei.
Lazar Adler NR, Allwood EM, Deveson Lucas D, Harrison P, Watts S, Dimitropoulos A, Treerat P, Alwis P, Devenish RJ, Prescott M, Govan B, Adler B, Harper M, Boyce JD
BMC Genomics 2016 May 4;17:331
PubMed ID: 27147217