Burkholderia pseudomallei K96243, BPSS1551 (orgA)

Gene Feature Overview

Strain	Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1 GCF_000011545.1|latest
Locus Tag	BPSS1551
Name	orgA Synonym: sctK
Replicon	chromosome 2
Genomic location	2104580 - 2105167 (+ strand)
Comment	This gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq	YP_111557.1
GI	53722572
Entrez	3096404
GI	53722572
INSDC	CAH39024.1
NCBI Locus Tag	BPSS1551
RefSeq	YP_111557.1,GeneID
UniParc	UPI000043BD31
UniProtKB Acc	Q63K15
UniProtKB ID	Q63K15_BURPS
UniRef100	UniRef100_A3P718
UniRef50	UniRef50_A3MCE7
UniRef90	UniRef90_A3MCE7

Product

Feature Type	CDS
Coding Frame	1
Product Name	type III secretion system ATPase co-factor OrgA (T3SS-3) Product Name Confidence: Class 2
Synonyms	Oxygen-regulated invasion protein OrgA Type III secretion system protein
Evidence for Translation
Charge (pH 7)	5.03
Kyte-Doolittle Hydrophobicity Value	0.071
Molecular Weight (kDa)	21177.1
Isoelectric Point (pI)	8.66

Subcellular localization

Individual Mappings	Localization Confidence PMID Unknown Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database	VFDB : VF0428
Category	T3SS-3
Evidence	ECO:0000314 direct assay evidence used in manual assertion
Host Organism
Notes
Reference	17984080

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 9 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG019862 (315 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BPSS1551 Search term: orgA Search term: type III secretion system ATPase co-factor OrgA (T3SS-3)

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei. Sun GW, Gan YH Trends Microbiol 2010 Dec;18(12):561-8 PubMed ID: 20951592

Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>. Vander Broek CW, Stevens JM Front Cell Infect Microbiol 2017;7:255 PubMed ID: 28664152