Burkholderia pseudomallei K96243, BPSS1547 (bsaM)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1547
Name
bsaM
Synonym: sctD
Replicon chromosome 2
Genomic location 2101717 - 2103003 (+ strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111553.1
GI 53722568
Entrez 3096220
GI 53722568
INSDC CAH39020.1
NCBI Locus Tag BPSS1547
RefSeq YP_111553.1,GeneID
UniParc UPI000043BD2D
UniProtKB Acc Q63K19
UniProtKB ID Q63K19_BURPS
UniRef100 UniRef100_Q63K19
UniRef50 UniRef50_A3MCF1
UniRef90 UniRef90_A3MCF1

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system inner membrane ring component BsaM (T3SS-3)
Product Name Confidence: Class 2
Synonyms type III secretion system protein
Evidence for Translation
Charge (pH 7) -3.90
Kyte-Doolittle Hydrophobicity Value -0.196
Molecular Weight (kDa) 46347.9
Isoelectric Point (pI) 6.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 13 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019855 (320 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1547
Search term: bsaM

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
PubMed ID: 24884837
Structural insights into the assembly of the type III secretion needle complex.
Marlovits TC, Kubori T, Sukhan A, Thomas DR, Galán JE, Unger VM
Science 2004 Nov 5;306(5698):1040-2
PubMed ID: 15528446
Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system.
Kubori T, Sukhan A, Aizawa SI, Galán JE
Proc Natl Acad Sci U S A 2000 Aug 29;97(18):10225-30
PubMed ID: 10944190