Burkholderia pseudomallei K96243, BPSS1543 (bsaQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1543
Name
bsaQ
Synonym: sctV
Replicon chromosome 2
Genomic location 2095478 - 2097550 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111549.1
GI 53722564
Entrez 3096684
GI 53722564
INSDC CAH39016.1
NCBI Locus Tag BPSS1543
RefSeq YP_111549.1,GeneID
UniParc UPI000043BD29
UniProtKB Acc Q63K23
UniProtKB ID Q63K23_BURPS
UniRef100 UniRef100_A0A097XQ27
UniRef50 UniRef50_D2UDE8
UniRef90 UniRef90_N0ARH3

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system export apparatus protein BsaQ (T3SS-3)
Product Name Confidence: Class 2
Synonyms Type III secretion system protein
Evidence for Translation
Charge (pH 7) -3.82
Kyte-Doolittle Hydrophobicity Value 0.552
Molecular Weight (kDa) 74415.8
Isoelectric Point (pI) 5.87

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 324 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019847 (326 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1543
Search term: bsaQ

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
Inactivation of Burkholderia pseudomallei bsaQ results in decreased invasion efficiency and delayed escape of bacteria from endocytic vesicles.
Muangsombut V, Suparak S, Pumirat P, Damnin S, Vattanaviboon P, Thongboonkerd V, Korbsrisate S
Arch Microbiol 2008 Dec;190(6):623-31
PubMed ID: 18654761
Caspase-1 dependent macrophage death induced by Burkholderia pseudomallei.
Sun GW, Lu J, Pervaiz S, Cao WP, Gan YH
Cell Microbiol 2005 Oct;7(10):1447-58
PubMed ID: 16153244