Burkholderia pseudomallei K96243, BPSS1528 (bapA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1528
Name
bapA
Replicon chromosome 2
Genomic location 2080097 - 2082739 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111534.1
GI 53722549
Entrez 3096284
GI 53722549
NCBI Locus Tag BPSS1528
RefSeq YP_111534.1,GeneID
UniProtKB Acc Q63K38
UniProtKB ID Q63K38_BURPS

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system effector protein BapA (T3SS-3)
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 20.79
Kyte-Doolittle Hydrophobicity Value -0.360
Molecular Weight (kDa) 87367.4
Isoelectric Point (pI) 11.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
direct assay evidence
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Pathogenic
Found only in pathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020946 (307 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1528
Search term: bapA

Human Homologs

References

The Burkholderia pseudomallei Proteins BapA and BapC Are Secreted TTSS3 Effectors and BapB Levels Modulate Expression of BopE.
Treerat P, Alwis P, D'Cruze T, Cullinane M, Vadivelu J, Devenish RJ, Prescott M, Adler B, Boyce JD
PLoS One 2015;10(12):e0143916
PubMed ID: 26624293
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152