Burkholderia pseudomallei K96243, BPSS1524 (bopA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1524
Name
bopA
Replicon chromosome 2
Genomic location 2075849 - 2077387 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111530.1
GI 53722545
Entrez 3096275
GI 53722545
INSDC CAH38997.1
NCBI Locus Tag BPSS1524
RefSeq YP_111530.1,GeneID
UniParc UPI000043BD16
UniProtKB Acc Q63K42
UniProtKB ID BOPA_BURPS
UniRef100 UniRef100_Q3JL32
UniRef50 UniRef50_A3MCH8
UniRef90 UniRef90_A3MCH8

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system effector protein BopA (T3SS-3)
Product Name Confidence: Class 1
Synonyms putative Type III secretion system effector protein
Evidence for Translation
Charge (pH 7) 23.44
Kyte-Doolittle Hydrophobicity Value -0.525
Molecular Weight (kDa) 56831.6
Isoelectric Point (pI) 10.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019823 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1524
Search term: bopA

Human Homologs

References

A genome-wide screen identifies a Bordetella type III secretion effector and candidate effectors in other species.
Panina EM, Mattoo S, Griffith N, Kozak NA, Yuk MH, Miller JF
Mol Microbiol 2005 Oct;58(1):267-79
PubMed ID: 16164564
Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines.
Cullinane M, Gong L, Li X, Lazar-Adler N, Tra T, Wolvetang E, Prescott M, Boyce JD, Devenish RJ, Adler B
Autophagy 2008 Aug;4(6):744-53
PubMed ID: 18483470
Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer.
Lin HY, Cheng CH, Chen DT, Chen YA, Park JY
Transl Cancer Res 2016 Oct;5(Suppl 5):S951-S963
PubMed ID: 28664150
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152