Burkholderia pseudomallei K96243, BPSS1523 (bicP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1523
Name
bicP
Synonym: sicP
Replicon chromosome 2
Genomic location 2075253 - 2075708 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111529.1
GI 53722544
Entrez 3096082
GI 53722544
INSDC CAH38996.1
NCBI Locus Tag BPSS1523
RefSeq YP_111529.1,GeneID
UniParc UPI000043BD15
UniProtKB Acc Q63K43
UniProtKB ID Q63K43_BURPS
UniRef100 UniRef100_A0A095QSH1
UniRef50 UniRef50_Q2T702
UniRef90 UniRef90_Q2T702

Product

Feature Type CDS
Coding Frame 1
Product Name
chaperone protein BicP
Product Name Confidence: Class 2
Synonyms putative Type III secretion system chaperone protein
Evidence for Translation
Charge (pH 7) -13.10
Kyte-Doolittle Hydrophobicity Value 0.009
Molecular Weight (kDa) 16308.1
Isoelectric Point (pI) 4.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 4 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019822 (317 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1523
Search term: bicP

References

A genome-wide screen identifies a Bordetella type III secretion effector and candidate effectors in other species.
Panina EM, Mattoo S, Griffith N, Kozak NA, Yuk MH, Miller JF
Mol Microbiol 2005 Oct;58(1):267-79
PubMed ID: 16164564
Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system.
Button JE, Galán JE
Mol Microbiol 2011 Sep;81(6):1474-83
PubMed ID: 21801239
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152
Identification of a specific chaperone for SptP, a substrate of the centisome 63 type III secretion system of Salmonella typhimurium.
Fu Y, Galán JE
J Bacteriol 1998 Jul;180(13):3393-9
PubMed ID: 9642193