Burkholderia pseudomallei K96243, BPSS1521 (bprD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1521
Name
bprD
Replicon chromosome 2
Genomic location 2073665 - 2074108 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus.

Cross-References

RefSeq YP_111527.1
GI 53722542
Entrez 3095465
GI 53722542
INSDC CAH38994.1
NCBI Locus Tag BPSS1521
RefSeq YP_111527.1,GeneID
UniParc UPI000043BD13
UniProtKB Acc Q63K45
UniProtKB ID Q63K45_BURPS
UniRef100 UniRef100_A0A097XM68
UniRef50 UniRef50_Q2T700
UniRef90 UniRef90_Q2T700

Product

Feature Type CDS
Coding Frame 1
Product Name
regulator and type III secretion system effector protein BbrD (T3SS-3)
Product Name Confidence: Class 1
Synonyms hypothetical protein
BprD
Evidence for Translation
Charge (pH 7) 16.92
Kyte-Doolittle Hydrophobicity Value -0.686
Molecular Weight (kDa) 16672.2
Isoelectric Point (pI) 11.42

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence used in manual assertion
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Pathogenic
Found only in pathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019819 (316 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1521
Search term: bprD

Human Homologs

References

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268
Characterization of BPSS1521 (bprD), a regulator of Burkholderia pseudomallei virulence gene expression in the mouse model.
Chirakul S, Bartpho T, Wongsurawat T, Taweechaisupapong S, Karoonutaisiri N, Talaat AM, Wongratanacheewin S, Ernst RK, Sermswan RW
PLoS One 2014;9(8):e104313
PubMed ID: 25111708
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152