Burkholderia pseudomallei K96243, BPSS1516 (bopC)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1516
Name
bopC
Replicon chromosome 2
Genomic location 2068764 - 2070173 (- strand)
CommentThis gene is part of the type III secretion system T3SS-3 (bsa) gene locus. bopC is also necessary for T6SS-1 function in macrophages (PMID: 21670170).

Cross-References

RefSeq YP_111522.1
GI 53722537
Entrez 3096078
GI 53722537
NCBI Locus Tag BPSS1516
RefSeq YP_111522.1,GeneID
UniProtKB Acc Q63K50
UniProtKB ID Q63K50_BURPS

Product

Feature Type CDS
Coding Frame 1
Product Name
type III secretion system effector BopC (T3SS-3)
Product Name Confidence: Class 1
Synonyms BopC
Evidence for Translation
Charge (pH 7) -2.01
Kyte-Doolittle Hydrophobicity Value -0.361
Molecular Weight (kDa) 51537.1
Isoelectric Point (pI) 6.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Cytoplasmic Class 3
Extracellular Class 1
Western blot evidence used in manual assertion
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0428
Category T3SS-3
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080

Pathogen Association Analysis

Results
Pathogenic
Found only in pathogenic strains
Hits to this gene were found in 3 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG020942 (270 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1516
Search term: bopC

Human Homologs

References

BopC is a type III secreted effector protein of Burkholderia pseudomallei.
Muangman S, Korbsrisate S, Muangsombut V, Srinon V, Adler NL, Schroeder GN, Frankel G, Galyov EE
FEMS Microbiol Lett 2011 Oct;323(1):75-82
PubMed ID: 22092682
Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.
Sun GW, Gan YH
Trends Microbiol 2010 Dec;18(12):561-8
PubMed ID: 20951592
Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268
Regulation of type VI secretion system during Burkholderia pseudomallei infection.
Chen Y, Wong J, Sun GW, Liu Y, Tan GY, Gan YH
Infect Immun 2011 Aug;79(8):3064-73
PubMed ID: 21670170
Type III Secretion in the Melioidosis Pathogen <i>Burkholderia pseudomallei</i>.
Vander Broek CW, Stevens JM
Front Cell Infect Microbiol 2017;7:255
PubMed ID: 28664152