Burkholderia pseudomallei K96243, BPSS1504 (tagAB-5)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1504
Name
tagAB-5
Replicon chromosome 2
Genomic location 2052905 - 2055547 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-5 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:21670170, PMID:22007185) and by the B. mallei literature (PMID:22892068, PMID:17555434).

Cross-References

RefSeq YP_111511.1
GI 53722526
Entrez 3095587
GI 53722526
INSDC CAH38977.1
NCBI Locus Tag BPSS1504
RefSeq YP_111511.1,GeneID
UniParc UPI000043BD03
UniProtKB Acc Q63K61
UniProtKB ID Q63K61_BURPS
UniRef100 UniRef100_Q63K61
UniRef50 UniRef50_I1WU91
UniRef90 UniRef90_I1WU91

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system-associated protein TagAB-5
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) -27.10
Kyte-Doolittle Hydrophobicity Value -0.170
Molecular Weight (kDa) 91342.3
Isoelectric Point (pI) 5.11

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0429
Category T6SS-1
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080
Source 2
Database BGD
Category T6SS-1
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes BPSS1504 is attenuated for virulence in BALB/c mice
Reference 24595140

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 242 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001150 (550 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1504
Search term: tagAB-5

Human Homologs

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
BPSS1504, a cluster 1 type VI secretion gene, is involved in intracellular survival and virulence of Burkholderia pseudomallei.
Hopf V, Göhler A, Eske-Pogodda K, Bast A, Steinmetz I, Breitbach K
Infect Immun 2014 May;82(5):2006-15
PubMed ID: 24595140
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434