Burkholderia pseudomallei K96243, BPSS1492 (bimA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS1492
Name
bimA
Replicon chromosome 2
Genomic location 2033784 - 2035334 (+ strand)

Cross-References

RefSeq YP_111499.1
GI 53722514
Entrez 3097017
GI 53722514
NCBI Locus Tag BPSS1492
RefSeq YP_111499.1,GeneID
UniProtKB Acc Q63K73
UniProtKB ID Q63K73_BURPS

Product

Feature Type CDS
Coding Frame 1
Product Name
Burkholderia intracellular motility A, BimA
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 3.90
Kyte-Doolittle Hydrophobicity Value -0.338
Molecular Weight (kDa) 51803.2
Isoelectric Point (pI) 9.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0427
Category Burkholderia intracellular motility A
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism
Notes
Reference 17984080
Source 2
Database BGD
Category Trimeric autotransporter
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes bimA mutation has reduced net intracellular replication in J774.2 murine macrophage-like cells
Reference 25830295

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 65 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002926 (1913 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS1492
Search term: bimA

Human Homologs

References

Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei.
Stevens MP, Stevens JM, Jeng RL, Taylor LA, Wood MW, Hawes P, Monaghan P, Welch MD, Galyov EE
Mol Microbiol 2005 Apr;56(1):40-53
PubMed ID: 15773977