Burkholderia pseudomallei K96243, BPSS0908 (bpaE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0908
Name
bpaE
Replicon chromosome 2
Genomic location 1200501 - 1202816 (+ strand)

Cross-References

RefSeq YP_110917.1
GI 53721932
Entrez 3096654
GI 53721932
INSDC CAH38370.1
NCBI Locus Tag BPSS0908
RefSeq YP_110917.1,GeneID
UniParc UPI000043BAC7
UniProtKB Acc Q63LV4
UniProtKB ID Q63LV4_BURPS
UniRef100 UniRef100_Q62BI8
UniRef50 UniRef50_Q2T564
UniRef90 UniRef90_Q2T564

Product

Feature Type CDS
Coding Frame 1
Product Name
BpaE
Product Name Confidence: Class 1
Synonyms surface-exposed protein
Evidence for Translation
Charge (pH 7) -11.84
Kyte-Doolittle Hydrophobicity Value 0.066
Molecular Weight (kDa) 73181.8
Isoelectric Point (pI) 4.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown (This protein may have multiple localization sites) Class 3
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database BGD
Category Trimeric autotransporter
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes bpaE mutation has reduced net intracellular replication in J774.2 murine macrophage-like cells
Reference 25830295

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 66 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG018701 (54 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0908
Search term: bpaE
Search term: BpaE

Human Homologs

References

Functional characterization of Burkholderia pseudomallei trimeric autotransporters.
Campos CG, Byrd MS, Cotter PA
Infect Immun 2013 Aug;81(8):2788-99
PubMed ID: 23716608