Burkholderia pseudomallei K96243, BPSS0879

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0879
Name
Replicon chromosome 2
Genomic location 1172547 - 1173671 (+ strand)

Cross-References

RefSeq YP_110888.1
GI 53721903
Entrez 3096508
GI 53721903
INSDC CAH38341.1
NCBI Locus Tag BPSS0879
RefSeq YP_110888.1,GeneID
UniParc UPI000043BAAC
UniProtKB Acc Q63LY3
UniProtKB ID Q63LY3_BURPS
UniRef100 UniRef100_Q3JFM7
UniRef50 UniRef50_Q3JPT3
UniRef90 UniRef90_A3MD10

Product

Feature Type CDS
Coding Frame 1
Product Name
porin protein
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724). Found in at least two preparations.
Charge (pH 7) 8.93
Kyte-Doolittle Hydrophobicity Value -0.303
Molecular Weight (kDa) 39178.6
Isoelectric Point (pI) 9.71

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Outer Membrane Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
Burkholderia pseudomallei Omp38 Heterologous expression of Burkholderia pseudomallei Omp38 (BpsOmp38) in Omp-deficient E. coli host cells lowers their permeability and in consequence, their antimicrobial susceptibility to penicillin G, cefoxitin, ceftazidime and imipenem. ARO:3004123 protein homolog model Strict 0.0 99.47 1.2.1

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 60 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG003726 (651 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0879
Search term: porin protein

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268