Burkholderia pseudomallei K96243, BPSS0516 (tssH-6)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0516
Name
tssH-6
Synonym: tssB-4
Replicon chromosome 2
Genomic location 703088 - 703636 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-4 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-2 cluster later (PMID:22007185)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-6 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-3 cluster later (PMID:22007185)

Cross-References

RefSeq YP_110537.1
GI 53721552
Entrez 3096828
GI 53721552
INSDC CAH37973.1
NCBI Locus Tag BPSS0516
RefSeq YP_110537.1,GeneID
UniParc UPI000043B94F
UniProtKB Acc Q63MY2
UniProtKB ID Q63MY2_BURPS
UniRef100 UniRef100_C4I8K9
UniRef50 UniRef50_L7ZP21
UniRef90 UniRef90_Q2T404

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssH-6
Product Name Confidence: Class 2
Synonyms type VI secretion system protein TssB-4
hypothetical protein
Evidence for Translation
Charge (pH 7) -15.51
Kyte-Doolittle Hydrophobicity Value -0.512
Molecular Weight (kDa) 20120.3
Isoelectric Point (pI) 4.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 108 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019178 (321 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0516
Search term: tssH-6

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434