Burkholderia pseudomallei K96243, BPSS0481 (hhqA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0481
Name
hhqA
Replicon chromosome 2
Genomic location 652895 - 654520 (+ strand)

Cross-References

RefSeq YP_110503.1
GI 53721518
Entrez 3096431
GI 53721518
INSDC CAH37937.1
NCBI Locus Tag BPSS0481
RefSeq YP_110503.1,GeneID
UniParc UPI000043B92D
UniProtKB Acc Q63N16
UniProtKB ID Q63N16_BURPS
UniRef100 UniRef100_Q0PKG5
UniRef50 UniRef50_A4YQI1
UniRef90 UniRef90_A3NHC2

Product

Feature Type CDS
Coding Frame 1
Product Name
HhqA
Synonyms
Evidence for Translation
Charge (pH 7) -0.12
Kyte-Doolittle Hydrophobicity Value 0.055
Molecular Weight (kDa) 58330.2
Isoelectric Point (pI) 6.99

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 601 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG017403 (474 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0481
Search term: hhqA
Search term: HhqA

Human Homologs

Ensembl 97, assembly GRCh38.p12
acyl-CoA synthetase medium chain family member 3 [Source:HGNC Symbol;Acc:HGNC:10522]
E-value: 3.7e-49
Percent Identity: 30.3

References

Functional genetic analysis reveals a 2-Alkyl-4-quinolone signaling system in the human pathogen Burkholderia pseudomallei and related bacteria.
Diggle SP, Lumjiaktase P, Dipilato F, Winzer K, Kunakorn M, Barrett DA, Chhabra SR, Cámara M, Williams P
Chem Biol 2006 Jul;13(7):701-10
PubMed ID: 16873018