Burkholderia pseudomallei K96243, BPSS0281 (gabT)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0281
Name
gabT
Replicon chromosome 2
Genomic location 375588 - 376871 (- strand)

Cross-References

RefSeq YP_110301.1
GI 53721316
Entrez 3095139
GI 53721316
INSDC CAH37728.1
NCBI Locus Tag BPSS0281
RefSeq YP_110301.1,GeneID
UniParc UPI000043B867
UniProtKB Acc Q63NL8
UniProtKB ID Q63NL8_BURPS
UniRef100 UniRef100_A0A069BDM0
UniRef50 UniRef50_P22256
UniRef90 UniRef90_Q2T3E2

Product

Feature Type CDS
Coding Frame 1
Product Name
4-aminobutyrate aminotransferase
Synonyms
Evidence for Translation
Charge (pH 7) -2.44
Kyte-Doolittle Hydrophobicity Value 0.206
Molecular Weight (kDa) 45118.5
Isoelectric Point (pI) 6.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 638 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004196 (646 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0281
Search term: gabT

Human Homologs

Ensembl 97, assembly GRCh38.p12
ornithine aminotransferase [Source:HGNC Symbol;Acc:HGNC:8091]
E-value: 5.3e-43
Percent Identity: 34.2

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268