Burkholderia pseudomallei K96243, BPSS0116 (tssH-2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0116
Name
tssH-2
Replicon chromosome 2
Genomic location 144273 - 146918 (+ strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-2 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-5 cluster later (PMID:22007185)

Cross-References

RefSeq YP_110137.1
GI 53721152
Entrez 3097105
GI 53721152
INSDC CAH37561.1
NCBI Locus Tag BPSS0116
RefSeq YP_110137.1,GeneID
UniParc UPI000043B7C4
UniProtKB Acc Q63P32
UniProtKB ID Q63P32_BURPS
UniRef100 UniRef100_Q63P32
UniRef50 UniRef50_Q9F746
UniRef90 UniRef90_Q2T907

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssH-2
Product Name Confidence: Class 2
Synonyms chaperone-related protein
Evidence for Translation
Charge (pH 7) -21.39
Kyte-Doolittle Hydrophobicity Value -0.008
Molecular Weight (kDa) 95257.7
Isoelectric Point (pI) 5.22

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 598 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG016113 (464 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0116
Search term: tssH-2

Human Homologs

Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 5.1e-32
Percent Identity: 30.8
Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 5.1e-32
Percent Identity: 30.8
Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 5.1e-32
Percent Identity: 30.8
Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 5.1e-32
Percent Identity: 30.8
Ensembl 97, assembly GRCh38.p12
ClpB homolog, mitochondrial AAA ATPase chaperonin [Source:HGNC Symbol;Acc:HGNC:30664]
E-value: 5.1e-32
Percent Identity: 30.8

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS
Microbiology 2007 Aug;153(Pt 8):2689-2699
PubMed ID: 17660433
Strategies for Intracellular Survival of Burkholderia pseudomallei.
Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD
Front Microbiol 2011;2:170
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D
Mol Microbiol 2007 Jun;64(6):1466-85
PubMed ID: 17555434