Burkholderia pseudomallei K96243, BPSS0099 (tssD-2)

Gene Feature Overview

Strain	Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1 GCF_000011545.1|latest
Locus Tag	BPSS0099
Name	tssD-2 Synonym: hcp5
Replicon	chromosome 2
Genomic location	120001 - 120483 (+ strand)
Comment	Gene is part of a cluster known as the type VI secretion system gene cluster tss-2 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-5 cluster later (PMID:22007185)

Cross-References

RefSeq	YP_110122.1
GI	53721137
Entrez	3096775
GI	53721137
INSDC	CAH37545.1
NCBI Locus Tag	BPSS0099
RefSeq	YP_110122.1,GeneID
UniParc	UPI000043B7B5
UniProtKB Acc	Q63P47
UniProtKB ID	Q63P47_BURPS
UniRef100	UniRef100_Q63P47
UniRef50	UniRef50_A3NFP4
UniRef90	UniRef90_A3P1G9

Product

Feature Type	CDS
Coding Frame	1
Product Name	type VI secretion system protein TssD-2 Product Name Confidence: Class 2
Synonyms	hypothetical protein
Evidence for Translation
Charge (pH 7)	-2.84
Kyte-Doolittle Hydrophobicity Value	-0.331
Molecular Weight (kDa)	17424.5
Isoelectric Point (pI)	6.00

Subcellular localization

Individual Mappings	Localization Confidence PMID Extracellular Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 70 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG020414 (309 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BPSS0099 Search term: tssD-2 Search term: type VI secretion system protein TssD-2

Human Homologs

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages. Shalom G, Shaw JG, Thomas MS Microbiology 2007 Aug;153(Pt 8):2689-2699 PubMed ID: 17660433

Strategies for Intracellular Survival of Burkholderia pseudomallei. Allwood EM, Devenish RJ, Prescott M, Adler B, Boyce JD Front Microbiol 2011;2:170 PubMed ID: 22007185

Type VI secretion is a major virulence determinant in Burkholderia mallei. Schell MA, Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D Mol Microbiol 2007 Jun;64(6):1466-85 PubMed ID: 17555434