Burkholderia pseudomallei K96243, BPSS0005 (kbl)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSS0005
Name
kbl
Replicon chromosome 2
Genomic location 3722 - 4921 (+ strand)

Cross-References

RefSeq YP_110029.1
GI 53721044
Entrez 3095061
GI 53721044
INSDC CAH37448.1
NCBI Locus Tag BPSS0005
RefSeq YP_110029.1,GeneID
UniParc UPI000043B758
UniProtKB Acc Q63PE0
UniProtKB ID Q63PE0_BURPS
UniRef100 UniRef100_A3P138
UniRef50 UniRef50_O75600
UniRef90 UniRef90_A1UXP7

Product

Feature Type CDS
Coding Frame 1
Product Name
2-amino-3-ketobutyrate CoA ligase
Synonyms
Evidence for Translation
Charge (pH 7) -2.01
Kyte-Doolittle Hydrophobicity Value 0.016
Molecular Weight (kDa) 42946.5
Isoelectric Point (pI) 6.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 514 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG004424 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSS0005
Search term: kbl

Human Homologs

Ensembl 97, assembly GRCh38.p12
glycine C-acetyltransferase [Source:HGNC Symbol;Acc:HGNC:4188]
E-value: 3.6e-118
Percent Identity: 56.1

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268