Burkholderia pseudomallei K96243, BPSL3187 (rpoA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL3187
Name
rpoA
Replicon chromosome 1
Genomic location 3795181 - 3796158 (- strand)

Cross-References

RefSeq YP_109781.1
GI 53720795
Entrez 3094313
GI 53720795
INSDC CAH37198.1
NCBI Locus Tag BPSL3187
RefSeq YP_109781.1,GeneID
UniParc UPI000043B66B
UniProtKB Acc Q63Q37
UniProtKB ID RPOA_BURPS
UniRef100 UniRef100_A3MRY0
UniRef50 UniRef50_A1JS01
UniRef90 UniRef90_Q2SU53

Product

Feature Type CDS
Coding Frame 1
Product Name
DNA-directed RNA polymerase subunit alpha
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (42.0 kDa, pI 6.09, PMID:21960737)
Charge (pH 7) -4.36
Kyte-Doolittle Hydrophobicity Value -0.145
Molecular Weight (kDa) 35684.7
Isoelectric Point (pI) 5.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 589 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000283 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3187
Search term: rpoA

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268