Burkholderia pseudomallei K96243, BPSL3107 (tssB-1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL3107
Name
tssB-1
Replicon chromosome 1
Genomic location 3712724 - 3713242 (- strand)
CommentGene is part of a cluster known as the type VI secretion system gene cluster tss-1 used in much of the early P. pseudomallei literature (PMID:17660433) but later referred to as T6SS-1 cluster later (PMID:22007185)

Cross-References

RefSeq YP_109702.1
GI 53720716
Entrez 3093725
GI 53720716
INSDC CAH37118.1
NCBI Locus Tag BPSL3107
RefSeq YP_109702.1,GeneID
UniParc UPI000043B61D
UniProtKB Acc Q63QB6
UniProtKB ID Q63QB6_BURPS
UniRef100 UniRef100_A0A069B4X3
UniRef50 UniRef50_B5E876
UniRef90 UniRef90_Q2SUC8

Product

Feature Type CDS
Coding Frame 1
Product Name
type VI secretion system protein TssB-1
Product Name Confidence: Class 2
Synonyms hypothetical protein
Evidence for Translation
Detected in B. pseudomallei strain DD503 using trypsin shaving and mass spectrometry (PMID:21391724). Found in at least two preparations.
Charge (pH 7) -1.99
Kyte-Doolittle Hydrophobicity Value -0.663
Molecular Weight (kDa) 19415.9
Isoelectric Point (pI) 5.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization
Detected in Triton-insoluble fraction of lysozyme-treated B. pseudomallei DD503 cells using trypsin shaving and mass spectrometry (PMID:21391724).

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 110 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000366 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL3107
Search term: tssB-1

References

In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.
Shalom G, Shaw JG, Thomas MS.
Microbiology. 2007 Aug;153(Pt 8):2689-99.
PubMed ID: 17660433
PubMed ID: 22007185
Type VI secretion is a major virulence determinant in Burkholderia mallei.
Schell MA(1), Ulrich RL, Ribot WJ, Brueggemann EE, Hines HB, Chen D, Lipscomb L, Kim HS, Mrázek J, Nierman WC, Deshazer D.
Mol Microbiol. 2007 Jun;64(6):1466-85.
PubMed ID: 17555434