Strain |
Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest |
Locus Tag |
BPSL3041
|
Name |
pacL
Synonym: paaZ Synonym: putative 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase |
Replicon | chromosome 1 |
Genomic location | 3630348 - 3632054 (+ strand) |
Comment | In E. coli, paaZ encodes a bifunctional protein consisting of an N-terminal NADP-dependent aldehyde dehydrogenase domain and a C-terminal MaoC-like (R)-specific enoyl-CoA hydratase domain. In Burkholderia genomes, a gene incorrectly annotated as paaZ (e.g WQ49_RS11500) encodes only one of the two domains found in E.coli paaZ (the domain with semialdehyde dehydrogenase activity) and so is renamed PacL (PMID:21296885) but was also referred to as PaaZ-ALDH in the manuscript. In the same study , a separate A. aromaticum, protein (UniProtKB:Q5P232) with the (R)-hydratase activity was annotated as Ech-Aa and the Burkholderia ortholog was annotated as PaaZ-ECH. |
RefSeq | YP_109636.1 |
GI | 53720650 |
Entrez | 3092152 |
GI | 53720650 |
INSDC | CAH37052.1 |
NCBI Locus Tag | BPSL3041 |
RefSeq | YP_109636.1,GeneID |
UniParc | UPI000043B5DB |
UniProtKB Acc | Q63QI2 |
UniProtKB ID | Q63QI2_BURPS |
UniRef100 | UniRef100_Q63QI2 |
UniRef50 | UniRef50_A1K261 |
UniRef90 | UniRef90_Q2SUJ2 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
PacL
|
Synonyms |
phenylacetic acid degradation oxidoreductase |
Evidence for Translation | |
Charge (pH 7) | -5.77 |
Kyte-Doolittle Hydrophobicity Value | -0.090 |
Molecular Weight (kDa) | 60603.9 |
Isoelectric Point (pI) | 6.28 |
Individual Mappings | |
Additional evidence for subcellular localization |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 476 genera
|
Burkholderia Ortholog Group |
BG000433 (655 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: BPSL3041
Search term: pacL
Search term: PacL
|
Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268
|
Studies on the mechanism of ring hydrolysis in phenylacetate degradation: a metabolic branching point.
Teufel R, Gantert C, Voss M, Eisenreich W, Haehnel W, Fuchs G
J Biol Chem 2011 Apr 1;286(13):11021-34
PubMed ID: 21296885
|
A functional phenylacetic acid catabolic pathway is required for full pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans host model.
Law RJ, Hamlin JN, Sivro A, McCorrister SJ, Cardama GA, Cardona ST
J Bacteriol 2008 Nov;190(21):7209-18
PubMed ID: 18776009
|