Burkholderia pseudomallei K96243, BPSL2988

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2988
Name
Replicon chromosome 1
Genomic location 3561445 - 3562383 (+ strand)

Cross-References

RefSeq YP_109582.1
GI 53720596
Entrez 3093473
GI 53720596
INSDC CAH36998.1
NCBI Locus Tag BPSL2988
RefSeq YP_109582.1,GeneID
UniParc UPI000043B5A6
UniProtKB Acc Q63QN6
UniProtKB ID Q63QN6_BURPS
UniRef100 UniRef100_A0A069BB50
UniRef50 UniRef50_Q2SZE4
UniRef90 UniRef90_Q2SZE4

Product

Feature Type CDS
Coding Frame 1
Product Name
sugar kinase
Synonyms
Evidence for Translation
Charge (pH 7) -8.72
Kyte-Doolittle Hydrophobicity Value -0.125
Molecular Weight (kDa) 34030.3
Isoelectric Point (pI) 5.35

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3B1R TRANSFERASE 07/05/11 Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in complex with AMP-Mg-AMP BURKHOLDERIA THAILANDENSIS 2.0 X-RAY DIFFRACTION 98.4
3B1P TRANSFERASE 07/05/11 Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in complex with ADP-inosine BURKHOLDERIA THAILANDENSIS 1.7 X-RAY DIFFRACTION 98.4
3B1O TRANSFERASE 07/05/11 Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in ligand-free form BURKHOLDERIA THAILANDENSIS 2.1 X-RAY DIFFRACTION 98.4
3B1Q TRANSFERASE 07/05/11 Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in complex with inosine BURKHOLDERIA THAILANDENSIS 1.7 X-RAY DIFFRACTION 98.4
3B1N TRANSFERASE 07/05/11 Structure of Burkholderia thailandensis nucleoside kinase (BthNK) in complex with ADP-mizoribine BURKHOLDERIA THAILANDENSIS 1.55 X-RAY DIFFRACTION 98.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 369 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000487 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2988
Search term: sugar kinase

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268