Burkholderia pseudomallei K96243, BPSL2690 (pyrB)

Gene Feature Overview

Strain	Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1 GCF_000011545.1|latest
Locus Tag	BPSL2690
Name	pyrB
Replicon	chromosome 1
Genomic location	3217614 - 3218645 (- strand)

Cross-References

RefSeq	YP_109286.1
GI	53720300
Entrez	3093493
GI	53720300
INSDC	CAH36698.1
NCBI Locus Tag	BPSL2690
RefSeq	YP_109286.1,GeneID
UniParc	UPI000043B493
UniProtKB Acc	Q63RI2
UniProtKB ID	PYRB_BURPS
UniRef100	UniRef100_A3MMA7
UniRef50	UniRef50_Q59711
UniRef90	UniRef90_A3MMA7

Product

Feature Type	CDS
Coding Frame	1
Product Name	aspartate carbamoyltransferase
Synonyms
Evidence for Translation
Charge (pH 7)	5.10
Kyte-Doolittle Hydrophobicity Value	-0.063
Molecular Weight (kDa)	37386.6
Isoelectric Point (pI)	9.01

Subcellular localization

Individual Mappings	Localization Confidence PMID Extracellular Class 1 quantitative mass spectrometry evidence 25635268 Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 647 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group	BG000722 (655 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: BPSL2690 Search term: pyrB Search term: aspartate carbamoyltransferase

Human Homologs

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants. Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM Mol Cell Proteomics 2015 Apr;14(4):905-16 PubMed ID: 25635268