Burkholderia pseudomallei K96243, BPSL2686 (rmlB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2686
Name
rmlB
Replicon chromosome 1
Genomic location 3212944 - 3214005 (- strand)

Cross-References

RefSeq YP_109282.1
GI 53720296
Entrez 3091967
GI 53720296
INSDC CAH36694.1
NCBI Locus Tag BPSL2686
RefSeq YP_109282.1,GeneID
UniParc UPI00000B282D
UniProtKB Acc H7C734
UniProtKB ID H7C734_BURPS
UniRef100 UniRef100_E5GAJ4
UniRef50 UniRef50_P55294
UniRef90 UniRef90_E5GAJ4

Product

Feature Type CDS
Coding Frame 1
Product Name
dTDP-glucose 4,6-dehydratase
Synonyms
Evidence for Translation
Charge (pH 7) -4.00
Kyte-Doolittle Hydrophobicity Value -0.340
Molecular Weight (kDa) 39131.6
Isoelectric Point (pI) 6.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 643 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000730 (655 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2686
Search term: rmlB

Human Homologs

Ensembl 97, assembly GRCh38.p12
TDP-glucose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:20324]
E-value: 1.3e-55
Percent Identity: 34.0

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268