Burkholderia pseudomallei K96243, BPSL2473 (thyA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2473
Name
thyA
Replicon chromosome 1
Genomic location 2982658 - 2983629 (- strand)

Cross-References

RefSeq YP_109066.1
GI 53720080
Entrez 3094644
GI 53720080
INSDC CAH36477.1
NCBI Locus Tag BPSL2473
RefSeq YP_109066.1,GeneID
UniParc UPI000043B3C8
UniProtKB Acc Q63S51
UniProtKB ID Q63S51_BURPS
UniRef100 UniRef100_A0A069B769
UniRef50 UniRef50_Q87UL4
UniRef90 UniRef90_Q2SXY2

Product

Feature Type CDS
Coding Frame 1
Product Name
thymidylate synthase
Synonyms
Evidence for Translation
Charge (pH 7) 0.56
Kyte-Doolittle Hydrophobicity Value -0.276
Molecular Weight (kDa) 36621.4
Isoelectric Point (pI) 7.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3V8H TRANSFERASE 12/22/11 Crystal structure of Thymidylate Synthase from Burkholderia thailandensis BURKHOLDERIA THAILANDENSIS 1.65 X-RAY DIFFRACTION 96.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 376 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG000927 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2473
Search term: thyA

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268