Burkholderia pseudomallei K96243, BPSL2344 (hutH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2344
Name
hutH
Replicon chromosome 1
Genomic location 2832481 - 2834004 (- strand)

Cross-References

RefSeq YP_108940.1
GI 53719954
Entrez 3091780
GI 53719954
INSDC CAH36347.1
NCBI Locus Tag BPSL2344
RefSeq YP_108940.1,GeneID
UniParc UPI000043B34B
UniProtKB Acc Q63SH6
UniProtKB ID HUTH_BURPS
UniRef100 UniRef100_A3NXA3
UniRef50 UniRef50_P21310
UniRef90 UniRef90_A3NXA3

Product

Feature Type CDS
Coding Frame 1
Product Name
histidine ammonia-lyase
Synonyms
Evidence for Translation
Charge (pH 7) -6.99
Kyte-Doolittle Hydrophobicity Value 0.244
Molecular Weight (kDa) 53110.2
Isoelectric Point (pI) 6.27

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 301 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002065 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2344
Search term: hutH

Human Homologs

Ensembl 97, assembly GRCh38.p12
histidine ammonia-lyase [Source:HGNC Symbol;Acc:HGNC:4806]
E-value: 9.6e-108
Percent Identity: 45.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268