Burkholderia pseudomallei K96243, BPSL2304 (folD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2304
Name
folD
Replicon chromosome 1
Genomic location 2777000 - 2777857 (+ strand)

Cross-References

RefSeq YP_108900.1
GI 53719914
Entrez 3094333
GI 53719914
INSDC CAH36307.1
NCBI Locus Tag BPSL2304
RefSeq YP_108900.1,GeneID
UniParc UPI000043B323
UniProtKB Acc Q63SL6
UniProtKB ID FOLD_BURPS
UniRef100 UniRef100_Q3JQL8
UniRef50 UniRef50_P51696
UniRef90 UniRef90_Q3JQL8

Product

Feature Type CDS
Coding Frame 1
Product Name
bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase
Synonyms
Evidence for Translation
Charge (pH 7) 2.80
Kyte-Doolittle Hydrophobicity Value 0.159
Molecular Weight (kDa) 29925.4
Isoelectric Point (pI) 8.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 621 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002033 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2304
Search term: folD

Human Homologs

Ensembl 97, assembly GRCh38.p12
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Source:HGNC Symbol;Acc:HGNC:7434]
E-value: 5.3e-63
Percent Identity: 48.3

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268