Burkholderia pseudomallei K96243, BPSL2285 (hscA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2285
Name
hscA
Replicon chromosome 1
Genomic location 2752735 - 2754603 (- strand)

Cross-References

RefSeq YP_108881.1
GI 53719895
Entrez 3092392
GI 53719895
INSDC CAH36288.1
NCBI Locus Tag BPSL2285
RefSeq YP_108881.1,GeneID
UniParc UPI000043B310
UniProtKB Acc Q63SN5
UniProtKB ID HSCA_BURPS
UniRef100 UniRef100_Q63SN5
UniRef50 UniRef50_Q8ZCS5
UniRef90 UniRef90_Q63SN5

Product

Feature Type CDS
Coding Frame 1
Product Name
chaperone protein HscA
Synonyms
Evidence for Translation
Charge (pH 7) -19.54
Kyte-Doolittle Hydrophobicity Value 0.022
Molecular Weight (kDa) 65767.1
Isoelectric Point (pI) 4.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Extracellular Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 638 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG002015 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2285
Search term: hscA

Human Homologs

Ensembl 97, assembly GRCh38.p12
heat shock protein family A (Hsp70) member 9 [Source:HGNC Symbol;Acc:HGNC:5244]
E-value: 6.9e-116
Percent Identity: 41.1

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268