Burkholderia pseudomallei K96243, BPSL2258 (dapA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2258
Name
dapA
Replicon chromosome 1
Genomic location 2723653 - 2724555 (- strand)

Cross-References

RefSeq YP_108854.1
GI 53719868
Entrez 3094346
GI 53719868
INSDC CAH36261.1
NCBI Locus Tag BPSL2258
RefSeq YP_108854.1,GeneID
UniParc UPI000043B2F5
UniProtKB Acc Q63SR2
UniProtKB ID Q63SR2_BURPS
UniRef100 UniRef100_A0A069B918
UniRef50 UniRef50_Q9JZR4
UniRef90 UniRef90_Q2SXB3

Product

Feature Type CDS
Coding Frame 1
Product Name
dihydrodipicolinate synthase
Synonyms
Evidence for Translation
Charge (pH 7) -1.42
Kyte-Doolittle Hydrophobicity Value 0.119
Molecular Weight (kDa) 31795.4
Isoelectric Point (pI) 6.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6MQH LYASE 10/09/18 Crystal structure of 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) from Burkholderia mallei BURKHOLDERIA MALLEI (STRAIN ATCC 23344) 1.7 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 633 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001988 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2258
Search term: dapA

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268