Burkholderia pseudomallei K96243, BPSL2245 (ppiA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2245
Name
ppiA
Replicon chromosome 1
Genomic location 2707966 - 2708541 (+ strand)

Cross-References

RefSeq YP_108840.1
GI 53719854
Entrez 3094185
GI 53719854
INSDC CAH36247.1
NCBI Locus Tag BPSL2245
RefSeq YP_108840.1,GeneID
UniParc UPI000043B2E7
UniProtKB Acc Q63SS6
UniProtKB ID Q63SS6_BURPS
UniRef100 UniRef100_A0A069B9E1
UniRef50 UniRef50_F8H4P1
UniRef90 UniRef90_A3NB52

Product

Feature Type CDS
Coding Frame 1
Product Name
peptidyl-prolyl cis-trans isomerase A
Synonyms
Evidence for Translation
Detected in B. pseudomallei strain 844 using MALDI-TOF/MS analysis (18.9 kDa, pI 6.59, PMID:21960737)
Charge (pH 7) 6.47
Kyte-Doolittle Hydrophobicity Value -0.145
Molecular Weight (kDa) 20392.3
Isoelectric Point (pI) 10.04

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Periplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 556 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG016822 (652 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2245
Search term: ppiA

Human Homologs

Ensembl 97, assembly GRCh38.p12
peptidylprolyl isomerase like 3 [Source:HGNC Symbol;Acc:HGNC:9262]
E-value: 7.2e-16
Percent Identity: 36.7

Human Homologs

Ensembl 97, assembly GRCh38.p12
peptidylprolyl isomerase like 3 [Source:HGNC Symbol;Acc:HGNC:9262]
E-value: 7.2e-16
Percent Identity: 36.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268