Burkholderia pseudomallei K96243, BPSL2204 (fabI)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2204
Name
fabI
Replicon chromosome 1
Genomic location 2647102 - 2647893 (+ strand)

Cross-References

RefSeq YP_108799.1
GI 53719813
Entrez 3091461
GI 53719813
INSDC CAH36206.1
NCBI Locus Tag BPSL2204
RefSeq YP_108799.1,GeneID
UniParc UPI000043B2BE
UniProtKB Acc Q63SW7
UniProtKB ID Q63SW7_BURPS
UniRef100 UniRef100_A0A069B9A4
UniRef50 UniRef50_P16657
UniRef90 UniRef90_N0AC56

Product

Feature Type CDS
Coding Frame 1
Product Name
enoyl-ACP reductase
Synonyms
Evidence for Translation
Charge (pH 7) -6.10
Kyte-Doolittle Hydrophobicity Value 0.247
Molecular Weight (kDa) 27770.3
Isoelectric Point (pI) 4.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5I9L OXIDOREDUCTASE 02/20/16 Crystal structure of B. pseudomallei FabI in complex with NAD and PT404 BURKHOLDERIA PSEUDOMALLEI 1.8 X-RAY DIFFRACTION 100.0
5I9N OXIDOREDUCTASE 02/20/16 Crystal structure of B. pseudomallei FabI in complex with NAD and PT412 BURKHOLDERIA PSEUDOMALLEI 2.512 X-RAY DIFFRACTION 100.0
5TRT OXIDOREDUCTASE 10/27/16 Crystal Structure of enoyl-(acyl carrier protein) reductase from Burkholderia pseudomallei 1710b bound to NAD BURKHOLDERIA PSEUDOMALLEI (STRAIN 1710B) 1.85 X-RAY DIFFRACTION 100.0
5I8Z OXIDOREDUCTASE 02/19/16 Crystal structure of B. pseudomallei FabI in complex with NAD and PT12 BURKHOLDERIA PSEUDOMALLEI 1.623 X-RAY DIFFRACTION 100.0
5IFL OXIDOREDUCTASE 02/26/16 Crystal structure of B. pseudomallei FabI in complex with NAD and triclosan BURKHOLDERIA PSEUDOMALLEI 2.6 X-RAY DIFFRACTION 100.0
4BKU OXIDOREDUCTASE 04/29/13 Enoyl-ACP reductase FabI from Burkholderia pseudomallei with cofactor NADH and inhibitor PT155 BURKHOLDERIA PSEUDOMALLEI 1.841 X-RAY DIFFRACTION 100.0
3EK2 OXIDOREDUCTASE 09/18/08 Crystal structure of eonyl-(acyl carrier protein) reductase from burkholderia pseudomallei 1719b BURKHOLDERIA PSEUDOMALLEI 1710B 1.9 X-RAY DIFFRACTION 100.0
5I9M OXIDOREDUCTASE 02/20/16 Crystal structure of B. pseudomallei FabI in complex with NAD and PT408 BURKHOLDERIA PSEUDOMALLEI 2.25 X-RAY DIFFRACTION 100.0
4RLH OXIDOREDUCTASE 10/17/14 Crystal structure of enoyl ACP reductase from Burkholderia pseudomallei in complex with AFN-1252 BURKHOLDERIA PSEUDOMALLEI 2.26 X-RAY DIFFRACTION 100.0
5I7F OXIDOREDUCTASE 02/17/16 Crystal structure of B. pseudomallei FabI in complex with NAD and PT405 BURKHOLDERIA PSEUDOMALLEI 2.7 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 605 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG019848 (328 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2204
Search term: fabI

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268