Burkholderia pseudomallei K96243, BPSL2197 (gltX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2197
Name
gltX
Replicon chromosome 1
Genomic location 2637135 - 2638544 (- strand)

Cross-References

RefSeq YP_108792.1
GI 53719806
Entrez 3093847
GI 53719806
INSDC CAH36199.1
NCBI Locus Tag BPSL2197
RefSeq YP_108792.1,GeneID
UniParc UPI000043B2B7
UniProtKB Acc Q63SX4
UniProtKB ID SYE_BURPS
UniRef100 UniRef100_A3NWS4
UniRef50 UniRef50_Q39F07
UniRef90 UniRef90_A3NWS4

Product

Feature Type CDS
Coding Frame 1
Product Name
glutamyl-tRNA synthetase
Synonyms
Evidence for Translation
Charge (pH 7) -8.15
Kyte-Doolittle Hydrophobicity Value -0.218
Molecular Weight (kDa) 52176.2
Isoelectric Point (pI) 5.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Extracellular Class 1
quantitative mass spectrometry evidence
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4G6Z LIGASE 07/19/12 Crystal structure of a glutamyl-tRNA synthetase GluRS from Burkholderia thailandensis bound to L-glutamate BURKHOLDERIA THAILANDENSIS 2.05 X-RAY DIFFRACTION 94.5

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 667 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001945 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2197
Search term: gltX

Human Homologs

Ensembl 97, assembly GRCh38.p12
glutamyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29419]
E-value: 2.4e-49
Percent Identity: 34.7

Human Homologs

Ensembl 97, assembly GRCh38.p12
glutamyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29419]
E-value: 2.4e-49
Percent Identity: 34.7

Human Homologs

Ensembl 97, assembly GRCh38.p12
glutamyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29419]
E-value: 2.4e-49
Percent Identity: 34.7

Human Homologs

Ensembl 97, assembly GRCh38.p12
glutamyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29419]
E-value: 2.4e-49
Percent Identity: 34.7

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268