Burkholderia pseudomallei K96243, BPSL2129 (guaB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2129
Name
guaB
Replicon chromosome 1
Genomic location 2557817 - 2559277 (- strand)

Cross-References

RefSeq YP_108726.1
GI 53719740
Entrez 3092041
GI 53719740
INSDC CAH36132.1
NCBI Locus Tag BPSL2129
RefSeq YP_108726.1,GeneID
UniParc UPI000043B276
UniProtKB Acc Q63T40
UniProtKB ID Q63T40_BURPS
UniRef100 UniRef100_A0A069B687
UniRef50 UniRef50_P21879
UniRef90 UniRef90_Q2SWW9

Product

Feature Type CDS
Coding Frame 1
Product Name
inosine 5'-monophosphate dehydrogenase
Synonyms
Evidence for Translation
Charge (pH 7) 2.75
Kyte-Doolittle Hydrophobicity Value 0.003
Molecular Weight (kDa) 51898.4
Isoelectric Point (pI) 7.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 638 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001881 (654 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2129
Search term: guaB

Human Homologs

Ensembl 97, assembly GRCh38.p12
inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052]
E-value: 5.6e-97
Percent Identity: 42.0
Ensembl 97, assembly GRCh38.p12
inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052]
E-value: 5.6e-97
Percent Identity: 42.0
Ensembl 97, assembly GRCh38.p12
inosine monophosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:6052]
E-value: 5.6e-97
Percent Identity: 42.0

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268