Burkholderia pseudomallei K96243, BPSL2127 (guaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2127
Name
guaA
Replicon chromosome 1
Genomic location 2555410 - 2557053 (- strand)

Cross-References

RefSeq YP_108724.1
GI 53719738
Entrez 3093632
GI 53719738
NCBI Locus Tag BPSL2127
RefSeq YP_108724.1,GeneID
UniProtKB Acc Q63T42
UniProtKB ID GUAA_BURPS

Product

Feature Type CDS
Coding Frame 1
Product Name
GMP synthase
Synonyms
Evidence for Translation
Charge (pH 7) -9.62
Kyte-Doolittle Hydrophobicity Value -0.088
Molecular Weight (kDa) 60173.5
Isoelectric Point (pI) 6.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Extracellular Class 1
quantitative mass spectrometry evidence
Cytoplasmic Class 3
Additional evidence for subcellular localization

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 653 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001879 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2127
Search term: guaA
Search term: GMP synthase

Human Homologs

Ensembl 97, assembly GRCh38.p12
guanine monophosphate synthase [Source:HGNC Symbol;Acc:HGNC:4378]
E-value: 2.2e-73
Percent Identity: 34.4

References

Quantitative proteomic analysis of Burkholderia pseudomallei Bsa type III secretion system effectors using hypersecreting mutants.
Vander Broek CW, Chalmers KJ, Stevens MP, Stevens JM
Mol Cell Proteomics 2015 Apr;14(4):905-16
PubMed ID: 25635268