Burkholderia pseudomallei K96243, BPSL2099 (ispD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Burkholderia pseudomallei K96243 - Assembly GCF_000011545.1
GCF_000011545.1|latest
Locus Tag
BPSL2099
Name
ispD
Replicon chromosome 1
Genomic location 2518595 - 2519305 (- strand)

Cross-References

RefSeq YP_108696.1
GI 53719710
Entrez 3092513
GI 53719710
INSDC CAH36102.1
NCBI Locus Tag BPSL2099
RefSeq YP_108696.1,GeneID
UniParc UPI000043B258
UniProtKB Acc Q63T70
UniProtKB ID ISPD_BURPS
UniRef100 UniRef100_A3MKM4
UniRef50 UniRef50_B4EC23
UniRef90 UniRef90_Q2SWT6

Product

Feature Type CDS
Coding Frame 1
Product Name
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) 2.11
Kyte-Doolittle Hydrophobicity Value -0.031
Molecular Weight (kDa) 25378.6
Isoelectric Point (pI) 8.10

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4YS8 TRANSFERASE 03/16/15 Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis BURKHOLDERIA THAILANDENSIS 2.45 X-RAY DIFFRACTION 97.9
4ZDQ TRANSFERASE 04/18/15 Crystal Structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) from Burkholderia thailandensis complexed with CTP BURKHOLDERIA THAILANDENSIS 2.3 X-RAY DIFFRACTION 97.9

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 528 genera

Orthologs/Comparative Genomics

Burkholderia Ortholog Group BG001806 (653 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: BPSL2099
Search term: ispD

Human Homologs

References

No references are associated with this feature.